| miércoles, 29 de junio de 2011 |
| Resultado | GANA | Derrota | SALV | Intento. |
| Cincinnati 4, en Tampa Bay 3 | Volquez (5-3) | Shields (8-5) | Cordero (16) | 25,968 |
| en Minnesota 1, LA Dodgers 0 | Baker (6-5) | De La Rosa (3-3) | Capps (13) | 39,655 |
| en San Diego 4, Kansas City 1 | Stauffer (4-5) | Chen (4-2) | Bell (23) | 24,461 |
| Atlanta 5, en Seattle 3 | Lowe (4-6) | Hernandez (8-7) | Kimbrel (23) | 30,472 |
| Cleveland 6, en Arizona 2 | Carrasco (8-4) | Duke (1-3) | | 26,876 |
| St. Louis 5, en Baltimore 1 | Carpenter (3-7) | Jakubauskas (2-1) | | 17,405 |
| en Angelinos de LA 1, Washington 0 | Haren (8-5) | Zimmermann (5-7) | Walden (18) | 35,257 |
| NY Mets 16, en Detroit 9 | Capuano (7-7) | Coke (1-8) | | 26,338 |
| en NY Yankees 5, Milwaukee 2 | Burnett (8-6) | Marcum (7-3) | Rivera (21) | 46,450 |
| en Philadelphia 2, Boston 1 | Worley (3-1) | Lackey (5-7) | Bastardo (3) | 45,612 |
| en Toronto 2, Pittsburgh 1 | Morrow (4-4) | Maholm (4-9) | Francisco (9) | 15,632 |
| en Cachorros Chicago 2, San Francisco 1 | Marmol (2-2) | Romo (3-1) | | 37,221 |
| Texas 3, en Houston 2 | Lewis (7-7) | Myers (3-7) | Feliz (16) | 24,472 |
| Medias Blancas Chicago 3, en Colorado 2 | Bruney (1-0) | Street (0-2) | Santos (16) | 35,973 |
| Florida 3, en Oakland 0 | Nolasco (5-4) | Moscoso (2-4) | | 17,006 |
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