| miércoles, 14 de septiembre de 2011 |
| Resultado | GANA | Derrota | SALV | Int.. |
| en Atlanta 4, Florida 1 | O'Flaherty (2-4) | Nolasco (10-11) | Kimbrel (44) | 22,245 |
| St. Louis 3, en Pittsburgh 2 | Jackson (5-2) | Morton (9-10) | Motte (7) | 12,520 |
| Toronto 5, en Boston 4 | Romero (15-10) | Bard (2-8) | Francisco (15) | 37,087 |
| Philadelphia 1, en Houston 0 | Halladay (18-5) | Norris (6-10) | | 20,027 |
| Detroit 6, en Medias Blancas Chicago 5 | Coke (3-9) | Santos (4-5) | Valverde (44) | 19,010 |
| Angelinos de LA 4, en Oakland 1 | Weaver (17-7) | Harden (4-3) | Walden (31) | 14,743 |
| en San Francisco 3, San Diego 1 | Lincecum (13-12) | Latos (7-14) | Casilla (3) | 41,209 |
| en Kansas City 7, Minnesota 3 | Hochevar (11-11) | Hendriks (0-2) | Holland (3) | 19,076 |
| en Texas 9, Cleveland 1 | Holland (14-5) | Huff (2-5) | | 38,710 |
| en Baltimore 6, Tampa Bay 2 | Guthrie (8-17) | Davis (10-9) | Johnson (6) | 14,669 |
| en Cincinnati 7, Cachorros Chicago 2 | LeCure (1-1) | Coleman (2-8) | | 18,304 |
| Washington 2, en NY Mets 0 | Peacock (1-0) | Pelfrey (7-12) | Storen (37) | 26,885 |
| Colorado 6, en Milwaukee 2 | Millwood (3-2) | Marcum (12-7) | | 38,302 |
| en Seattle 2, NY Yankees 1 | Delabar (1-0) | Wade (5-1) | | 20,327 |
| en LA Dodgers 3, Arizona 2 | Kershaw (19-5) | Hudson (16-10) | Jansen (4) | 29,799 |
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